Oh…. Oh…………… ;_; indeed. Wow.

Here’s the study for more info

And a quick reader friendly summary of the findings

It’s always kind of been a bullshit “symptoms syndrome,” “go away shut up ‘diagnosis’” to me, which was NOT helped by there being no treatment ever offered other than “exercise and improve your mental health you’re just lazy and depressed and anxious and feeling exertion makes you more anxious (saying ‘exertion/exercise intolerance’ makes you go to hell for real) go to therapy” so like. actually seeing solid well researched evidence that no I’m not just a pathetic stupid clumsy weak person with no distress tolerance as I’ve very much internalized…. I am undone.

I’m getting genuinely emotional y’all don’t understand how ISOLATING it can be when cultural dress for most other Asian countries are popular and represented and Filipino clothing barely is, LET ALONE PRE-COLONIAL?!

I- 🥹

I hope to find the time and energy to fulfil my dream of making the clothes and dressing like this

Angel of War, angular and strange, gleaming silver and gold,
Angel of Wonder, pure and one-eyed, looking to stars new and old,
Angel of Harvest, simple and hidden, bring nature's sweetness to all,
Angel of Health, mysterious and fine, beacon when life starts to fall,
Angel of the Deep, crooked and cage-like, guide us across the sea,
Angel of Solace, protect us from evil, lead us to where we are free.

@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.

The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.

The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.

But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.

Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.

If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:

• We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.
• We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.
• We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.
• We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.

I could go on, and on, and on.

The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.

These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.

But the cost of expediting science could mean a life of profoundly greater suffering or an even shorter life than the one where no intervention happens at all. And at that point, you have completely exhausted your trust, your goodwill, and your patients' hope, after you've failed to do anything or even worsened the lives of people who are already deeply suffering.

hi, i’m an animal research professional. making sure laboratory animals stay alive, healthy, and enriched has been my full-time job for several years now.

animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.

not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.

let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.

research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).

research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.

some research animal fun facts (US edition):

• all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.
• institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.
• institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.
• a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.
• some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.

so yes, you can rest knowing that laboratory animals are treated with the utmost respect by their caretakers. and you can stop this awful, ignorant talk of human experimentation that will only end in the abuse of nonwhite people, LGBT people, disabled people, indigenous people, and so many others. please just take a look at this wikipedia page if you think “ethical” human experimentation can exist.

One of the biggest ways to eliminate waste of life is to challenge intellectual property, for profit medicine and ultimately capitalism and borders.

Competition in developing medicine is one of many avoidable wastes of lab animal life.

Competition among cosmetic companies as well.

June 12, 2016. Putting a date on this for when it gets reblogged months from now by people who think the post is about something from 30, 40 years ago.

I am a survivor of the Pulse nightclub shooting, having grown up in Orlando and just turned 20 a month prior. If you didn’t know, there were several families who refused to claim the bodies of their relatives due to their sexuality. One family even had their relative’s name removed from the memorial. Murdered by the same hate with which their families reject them in both life and death.

Many, many people celebrated Pulse. We were told we deserved it. That it was God’s punishment for our sin of loving the same sex. We are sent messages like these I received in 2018:

We in the community often call the victim count 49+ to include the survivors who couldn’t live with the pain.

The event was never officially declared a hate crime or targeted homophobic attack and is rarely listed as one in databases.

At our vigils for those slaughtered, Extremist Christian groups showed up to protest, holding signs like this:

ID: Me kissing a woman I was casually seeing in front of an angry looking man with a “Sodomy is Sin” sign.

Please understand how much more than just a mass shooting this was. We are still to this day harassed and told we deserved it by some.

This year was the sixth anniversary. The first couple years I received dozens of messages checking in on me on 6/12. Year 5 got enough news coverage for people to think to reach out to me. This year it was my therapist, the woman I kissed in that photo, and a couple of other gun violence survivor friends. People are forgetting already.

With the 7 year anniversary <2 weeks away, I figured I’d reblog this

You go down the stairwell/fire escape. Is that weird?

But what if you have a walker or a wheelchair??

in america at least, in this situation, there isnt one. either your loved ones or the firemen can get you out using the emergency fire escapes or stairs, or you die 

That's fucking horrific, thank you

“fun” little story:

last summer my friend who is an amazingly talented artist and i were in this super tall building, and she’s in a wheelchair and i’m pushing her around the room. it’s an art exhibit and some of her art was chosen to be showcased there and so it’s all fine and dandy until suddenly an alarm starts going off

a FIRE ALARM

everyone starts running for the stairs and my friend just looks at me with this forlorn look on her face

“i can’t go down the stairs”

but i’m a stubborn bitch “i’ll carry you”

“what about my chair? it’s too expensive for me to be able to get another one if i can’t get this one back”

“i’ll carry that too”

and i did. we went to the stairs (by then most people from our floor were gone) and i lifted her up in a fireman’s carry over my shoulder and then lifted her chair up and used the ridiculous amount of adrenaline that was coursing through my veins to make it down approximately 20 half-flights of stairs until we met some people exiting lower floors, one of which who kindly took the chair. I changed positions so i was holding my friend bridal-style which was, somehow, easier and the person who took her wheelchair (with her permission to handle it of course) accompanied me to the ground floor and then out the doors

basically there is no real protocol for people who can’t use the stairs in an emergency. it’s up to the people with them, if anyone, to help them or the person to somehow make it down the stairs alone, unassisted

thank fuck that it was just a faulty alarm system, because if i was unable to carry her down those stairs and the building was on fucking fire???? then i don’t know what would have happened to her, but i don’t think it would have been very good.

it’s fucking ridiculous and ableist to the absolute max.

I use a cane. When I did a day-long fire safety training at my northeast American university (UMass Amherst), I asked that exact same question: “what am I supposed to do if the fire alarm goes off and I’m in my lab on the twelfth floor?” 

the fire marshal hemmed and hawed for a while and then said to take the elevator- you’re supposed to leave it free for the fire department to use and they want able-bodied people out fast not waiting for elevators. if the fire alarm has just gone off the building probably hasn’t suffered enough structural damage to make using the elevator dangerous, and modern elevator wells are heavily reinforced. many large and high-trafficked buildings on my campus have fire rated elevators that link in with the fire alarm system so they won’t let you off on a floor with a possible fire. 

if the elevator isn’t working, wait in the stairwell and call the fire department to let them know where you are. modern stairwells are also heavily reinforced- it might not be pleasant but modern building code usually requires fire-resistant stairwell doors in office and big residential buildings, also to help firefighters get in and out safely. older buildings’ stairwells may or may not be retrofitted with fire-resistant doors but a stairwell is generally the safest place to wait if you can’t get out. 

what happened to your friend was horrible, and i’m very glad you were there to help her out, but you can absolutely use the elevator to evacuate if it’s not shut down. those don’t-use-the-elevator rules are for abled people.  

This is GOOD TO KNOW. why do they not tell people this??

Okay, firefighter here. If you are not physically able to use the stairs, and the elevator is NOT compromised, use the elevator. But you MUST be ABSOLUTELY CERTAIN that the elevator is NOT compromised before you get into it, because there is always the chance that once you get into it, you may not exit it. Power could go out. The elevator may actually BE compromised and you just couldn’t tell from where you were until you were in there, and it suddenly shuts down on you. Something else could happen. 

Understand that once you enter the elevator, you could POTENTIALLY be taking your life into your hands there.

It is NOT LIKELY, to be perfectly honest. It’s only in a pretty catastrophic scenario - think the Twin Towers, USA, on September 11th - that the elevators will be compromised and out of service. But there is a NOT ZERO PERCENT CHANCE and you need to understand that and accept it.

As for leaving the elevators free for the firefighters, okay, here’s the deal. Unless your nearest fire station is literally right next door? Your first on scene fire truck is NOT likely to be there on scene and needing that elevator before you get to the ground. It takes us TIME to find the address, gear up, and drive to the building. Then we need to hoof it into where the elevators even ARE, so YOU HAVE TIME to use the elevator to get down to the ground floor... BUT ONLY IF THERE’S NOT A RUSH ON THE ELEVATOR! And THAT is WHY we don’t tell people this shit. That’s WHY we tell people to NEVER USE THE ELEVATOR... because every self-entitled asshole will use it because they don’t feel like walking, and then put YOU in danger by delaying the elevator’s arrival to you.

IF, however, the elevator IS compromised, or you just can’t get it to come for you, or whatever, and you either don’t have anyone with you who has the adrenaline fueled BALLS to be able to toss you over their shoulder and hoof it down the stairs with you - because, let’s face it, that is RARE AS FUCK, then HERE IS WHAT YOU DO:

You call 911 and tell the call taker that you are in the building that has a fire alarm going off, and you are not able to evacuate because of a physical disability, and you tell them what floor you are on, and EXACTLY what stairwell you are waiting at. And the very FIRST thing that the firefighters are going to do once they arrive, if it is, indeed, a REAL emergency, and not a false alarm, is come get your ass and bring you down. Whether that means carrying you down the stairs, or whether that means locking out the elevators so that no one else can override them and coming to get you themselves, they WILL come get you FIRST THING if it is a real event. And if it is a false alarm? You will probably be the first person who is not involved with the building to know, because the call-taker is going to stay on the line with you until you are under someone’s care and out of danger, or until the scene has been sorted out as real or false, and you are out of danger that way.

These are pretty standard operations in the fire service throughout the United States. There may be some minor variations based on specific municipalities, but, for the most part, this is pretty typical: LIFE BEFORE PROPERTY. So, as long as SOMEONE knows where you are - hence why you call 911 - Firefighters will come get you. You are NOT alone, and you have NOT been abandoned. I PROMISE. It’s like, our whole reason for doing the shit we do: to save lives and to break shit. Sometimes, we get lucky enough to do both at the same time.

High rise fires suck ass, and I always hated them. But the very FIRST thing I asked anytime we got one was if we had “any entrapments” - which is what we call anyone who could not self-evacuate for ANY reason. We ain’t leaving you behind. And yes, your friend who doesn’t have the stamina to carry you down can stay with you, too. Because I would never ask that of someone, honestly. 

Also, just a little FYI... MOST fire alarms are false alarms. Not to make anyone complacent or anything, but, yeah. Most of them are either system malfunctions, someone accidentally hit a pull station, or someone burned popcorn in a break room. So don’t let a fire alarm freak you out until you need it to - by smelling or seeing smoke or flames. 

i have had multiple nightmares about this very thing because NOBODY BOTHERS TO ACTUALLY TELL WHEELCHAIR USERS THIS STUFF